The Metabolomix+ is a unique combination of nutritional tests that provides an analysis of key nutritional biomarkers. A first morning void (FMV) urine collection, with optional add-on bloodspot finger stick and buccal swab, the Metabolomix+ nutritional test is a non-invasive, patient-friendly way to assess the functional need for antioxidants, B-vitamins, minerals, digestive support, fatty acids, and amino acids. Insights gained from the Metabolomix+ nutritional test allows clinicians to target nutritional therapies to the precise needs of their patients. Marked accumulation of organic acids in urine can signal a metabolic inhibition or block. The metabolic block may be due to a nutrient deficiency, an inherited enzyme deficit, toxic build-up, or drug effect. Enzymes that are responsible for metabolizing organic acids are vitamin and mineral dependent. With this, elevations in organic acids can reflect a functional need for these nutrients on a cellular and biochemical level, even despite normal serum levels. Recommendations for nutrient supplementation based on elevated organic acid results are generated using a literature-based proprietary algorithm. Traditionally, urinary organic acid assessment has been used in neonatal/pediatric medicine to identify genetic inborn errors of metabolism, with severity depending on the degree and type of error. In many cases of genetic inborn errors, the enzymatic defect may be compensated for by high doses of specific vitamin and mineral cofactors and/or dietary interventions. Intervention with higher-dose nutrient cofactors may also be effective in cases of decreased enzyme activity due to causes other than frank inborn errors. Organic Acids Malabsorption and Dysbiosis Cellular Energy and Mitochondrial Metabolites Neurotransmitter Metabolites Vitamin Markers Toxin and Detoxification Markers Tyrosine Metabolism Amino Acids Nutritionally Essential Amino Acids Nonessential Protein Amino Acids Intermediary Metabolites Dietary Peptide Related Markers Oxidative Stress Markers Essential and Metabolic Fatty Acids - Bloodspot (if selected as an add-on) Omega 3 Fatty Acids Omega 6 Fatty Acids Omega 9 Fatty Acids Saturated Fatty Acids Monounsaturated Fatty Acids Delta-6 Desaturase Activity Cardiovascular Risk Additional Biomarkers Available for add-on at additional cost: MTHFR (C677T & A1298C) COMT (V158M) APOE TNF-a Toxic Element Clearance Profile or Comprehensive Urine Elements can be ordered as an add-on. Both cannot be ordered at the same time. Toxic Element Clearance Profile (if selected as an add-on at an additional cost) Aluminum Antimony Arsenic Barium Bismuth Cadmium Cesium Creatinine Gadolinium Gallium Lead Mercury Nickel Niobium Platinum Rubidium Sulfur Thallium Thorium Tin Tungsten Uranium Comprehensive Urine Elements (if selected as an add-on at an additional cost): Aluminum Antimony Arsenic Barium Bismuth Cadmium Calcium Cesium Chromium Cobalt Copper Creatinine Gadolinium Gallium Iron Lead Lithium Magnesium Manganese Mercury Molybdenum Nickel Niobium Platinum Potassium Rubidium Selenium Strontium Sulfur Thallium Thorium Tin Tungsten Uranium Vanadium Zinc Additional Biomarkers Available for add-on at additional cost: MTHFR (C677T & A1298C) COMT (V158M) APOE TNF-a