Every basket follows standard-of-care escalation: screen first, confirm if abnormal, specialist follow-up only when warranted. Any bundle opens the matrix — the cheapest retailer that stocks the full set.
| # | Bundle | Tier | Markers | Cheapest | At | |
|---|---|---|---|---|---|---|
| 01 | Annual Physical CBC · CMP · Lipid · TSH · Vitamin D | T1 · Screen | 5 | $36 | Goodlabs · 26 carry all | → |
| 02 | Wellness Baseline Physical + HbA1c · ferritin · hs-CRP · B12 | T2 · Confirm | 9 | $64 | Goodlabs · 23 carry all | → |
| 03 | Heart Screen Lipid panel · hs-CRP · HbA1c | T1 · Screen | 3 |
Annual-physical-equivalent panels. The baseline for anyone.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Annual Physical CBC · CMP · Lipid · TSH · Vitamin D › Everyone 18+› Yearly, asymptomatic | Replicates the default wellness-visit order. Screens metabolic, kidney, liver, thyroid, inflammation + vitamin D in one draw. | 5 | → |
| T2 · Confirm | Wellness Baseline Physical + HbA1c · ferritin · hs-CRP · B12 › Anyone 30+, or 18+ with family history | Annual physical + the four most actionable add-ons: diabetes (HbA1c), iron (ferritin), inflammation (hs-CRP), nerve-function (B12). |
Type any marker names and the matrix finds the single retailer that carries them all for the lowest total.
| Goodlabs · 30 carry all |
| → |
| 04 | Advanced Lipids Lipid · apoB · Lp(a) · homocysteine · hs-CRP | T2 · Confirm | 5 | $54 | Goodlabs · 22 carry all | → |
| 05 | Men's Hormone Panel Total T · Free T · SHBG · Estradiol · DHEA-S | T2 · Confirm | 5 | $42 | Goodlabs · 20 carry all | → |
| 06 | Longevity Advanced Baseline + apoB · Lp(a) · homocysteine · DHEA-S | T2 · Confirm | 8 | $83 | Goodlabs · 22 carry all | → |
| 07 | Diabetes Screen Glucose · HbA1c | T1 · Screen | 2 | $12 | Goodlabs · 29 carry all | → |
| 08 | Insulin Resistance Glucose · HbA1c · insulin · C-peptide · HOMA-IR | T2 · Confirm | 5 | $93 | Instalab · 2 carry all | → |
| 9 |
| → |
| T3 · Advanced | Executive Physical Wellness + apoB · Lp(a) · homocysteine · thyroid extended › Comprehensive annual baseline | What a concierge practice orders. Adds residual cardiovascular risk (apoB, Lp(a)), methylation (homocysteine), full thyroid, and micronutrients to the wellness baseline. | 16 | → |
Beyond LDL. Residual-risk stratification.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Heart Screen Lipid panel · hs-CRP · HbA1c › Anyone 35+ | The three markers that drive 80% of cardiovascular risk stratification at the population level. | 3 | → |
| T2 · Confirm | Advanced Lipids Lipid · apoB · Lp(a) · homocysteine · hs-CRP › Family history of early heart disease | apoB is a better LDL than LDL. Lp(a) is genetic (test once). Homocysteine + hs-CRP catch the risk LDL misses. | 5 | → |
| T3 · Advanced | Cardio Specialist Advanced + oxidized LDL · fibrinogen · NT-proBNP › Prior event, or advanced lipidology workup | Oxidized LDL is the atherogenic form. Fibrinogen flags coagulation risk. NT-proBNP stratifies heart-failure risk. | 8 | → |
Glucose, insulin, and the road to type 2.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Diabetes Screen Glucose · HbA1c › Anyone 35+, or BMI > 25 | Fasting glucose is a single-point snapshot; HbA1c averages 3 months. Both together catch prediabetes. | 2 | → |
| T2 · Confirm | Insulin Resistance Glucose · HbA1c · insulin · C-peptide · HOMA-IR › Belly fat, fatigue, family history of T2D | Fasting insulin rises years before HbA1c does. C-peptide distinguishes endogenous insulin. HOMA-IR is the calculated resistance score. | 5 | → |
| T3 · Advanced | Metabolic Deep-Dive IR panel + glycomark · triglycerides · HDL | GlycoMark flags post-prandial glucose spikes HbA1c misses. TG:HDL ratio > 3 is a strong insulin-resistance marker. | 8 | → |
TSH alone misses half of thyroid dysfunction.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Thyroid Screen TSH › Screening only | TSH alone catches overt hypo/hyperthyroidism. First-line per USPSTF for fatigue, weight change, or family history. | 1 | → |
| T2 · Confirm | Thyroid Panel TSH · Free T4 · Free T3 › Symptoms despite normal TSH | TSH can be normal while free hormones are low (central hypothyroidism, T3 conversion issues). This catches subclinical dysfunction. | 3 | → |
| T3 · Advanced | Thyroid Complete Panel + reverse T3 · TPO · Tg antibodies › Suspected Hashimoto's, Graves', or atypical presentation | Reverse T3 flags conversion issues. TPO + Tg antibodies diagnose Hashimoto's. This is the full workup your endocrinologist orders. | 6 | → |
Androgen, estrogen, and pituitary axis.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Men's Basic Testosterone · PSA › Men 35+ | Total T for androgen status; PSA for prostate screening. Two tests that cover the two most common concerns in men over 40. | 2 | → |
| T2 · Confirm | Men's Hormone Panel Total T · Free T · SHBG · Estradiol · DHEA-S › Low libido, fatigue, mood, body composition issues | Total T can mislead — SHBG traps testosterone, making it unavailable. Free T is the active fraction. Estradiol checks aromatization. DHEA-S is the adrenal precursor. | 5 | → |
| T3 · Advanced | Men's Advanced Panel + LH · FSH · prolactin · IGF-1 · cortisol › Abnormal T + workup before TRT | LH + FSH localize low T to pituitary vs testes. Prolactin rules out pituitary tumor. IGF-1 checks growth hormone. Cortisol + DHEA-S give HPA-axis status. | 10 | → |
Cycle-aware reproductive panels.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Women's Baseline TSH · FSH · Estradiol › Women 30+ | TSH rules out thyroid; FSH tells you where you are in the menopause transition; estradiol gives current estrogen status. | 3 | → |
| T2 · Confirm | Women's Cycle Panel Estradiol · Progesterone · LH · FSH · Prolactin · Testosterone › Cycle irregularity, fertility workup | Cycle-timed (day 3 for FSH/LH/estradiol, day 21 for progesterone). Catches PCOS, anovulation, luteal-phase defects. | 6 | → |
| T3 · Advanced | Women's Perimenopause Cycle + AMH · DHEA-S · cortisol · SHBG › Age 40-55, cycle changes, symptoms | AMH is the best ovarian-reserve marker. DHEA-S + cortisol catch adrenal contribution. SHBG drops in peri, freeing androgens. | 10 | → |
Vitamin, mineral, and methylation status.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Vitamin Baseline Vitamin D · B12 · folate · ferritin › Fatigue, plant-based diet, or post-60 | The four deficiencies most commonly flagged on a physical. D drives bone + immune; B12 + folate drive energy + cognition; ferritin catches iron stores. | 4 | → |
| T2 · Confirm | Comprehensive Vitamins Baseline + A · E · K · magnesium · zinc | Fat-soluble vitamins (A, E, K) show absorption issues. Magnesium + zinc are the two minerals commonly low even on a good diet. | 9 | → |
| T3 · Advanced | Methylation & MTHFR Homocysteine · B12 · folate · B6 › High homocysteine, known MTHFR variant | High homocysteine + low B12/folate/B6 = impaired methylation. Common in MTHFR C677T carriers (~12% of population). | 4 | → |
Hemoglobin low? Start here.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Iron Screen CBC · ferritin › Fatigue, heavy periods, endurance athletes | CBC shows hemoglobin + MCV (microcytic → iron-deficient). Ferritin is the most sensitive marker for depleted stores. | 2 | → |
| T2 · Confirm | Iron Complete CBC · ferritin · iron · transferrin › Low ferritin + elevated inflammation | Ferritin can be falsely high with inflammation. Serum iron + transferrin gives a second look at bioavailable iron. | 4 | → |
Systemic inflammation + autoimmune screen.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Inflammation Screen hs-CRP · ESR | The two cheapest, most sensitive markers for systemic inflammation. hs-CRP flags acute + cardiovascular; ESR is chronic. | 2 | → |
| T2 · Confirm | Extended Inflammation hs-CRP · ESR · ferritin · fibrinogen · homocysteine | Ferritin doubles as inflammation marker in context. Fibrinogen flags coagulation-related inflammation. Homocysteine ties back to cardiovascular risk. | 5 | → |
| T3 · Advanced | Autoimmune Screen ANA · rheumatoid factor · hs-CRP · ESR › Joint pain, rashes, unexplained symptoms | ANA screens for lupus + related connective-tissue disease. RF flags rheumatoid arthritis. Both with inflammation markers. | 4 | → |
Hepatic enzymes, bile, and hepatitis.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Liver Screen ALT · AST · bilirubin · albumin › On medications, alcohol use, elevated BMI | The four markers inside every CMP. ALT/AST flag hepatocyte damage; bilirubin + albumin flag synthetic function. | 4 | → |
| T2 · Confirm | Liver Panel Complete Screen + GGT · ALP · LDH · globulin | GGT catches alcohol + bile-duct issues. ALP rises in bone + bile. LDH is non-specific but sensitive. Globulin catches chronic inflammation + immune disorders. | 8 | → |
Glomerular filtration + tubular markers.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Kidney Screen BUN · creatinine · eGFR › Diabetes, hypertension, family history of CKD | The three markers inside every CMP. eGFR is the staged kidney-disease metric. | 3 | → |
| T2 · Confirm | Kidney Complete Screen + cystatin C · urinalysis | Cystatin C doesn't depend on muscle mass, so it's more accurate in the elderly + athletes. Urinalysis catches proteinuria (the earliest sign of diabetic kidney damage). | 5 | → |
STI screen + confirmatory testing.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | STI Core Chlamydia · gonorrhea · syphilis (RPR) › Annually, or after new partner | The CDC-recommended annual screen for sexually active adults under 25, and for anyone with new partners. | 3 | → |
| T2 · Confirm | STI Extended Core + HSV-1 · HSV-2 · hepatitis B › Risk-based expansion or symptomatic | Adds herpes serology (HSV-1/2 differentiation) and hepatitis B surface antigen. Covers the main risk-based extensions. | 6 | → |
Inflammation, flora, and digestive function.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Gut Screen H. pylori · occult blood › Upper GI symptoms, age 45+ for occult blood | H. pylori drives most gastric ulcers + a fraction of gastric cancer. Fecal occult blood is the cheapest colorectal-cancer screen. | 2 | → |
| T2 · Confirm | Gut Function Screen + calprotectin · elastase · secretory IgA | Calprotectin distinguishes IBD from IBS. Elastase measures pancreatic function. Secretory IgA is gut-immune status. | 5 | → |
Calcium axis + vitamin D + PTH.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T2 · Confirm | Bone Complete Vitamin D · calcium · phosphorus · magnesium · PTH › Post-menopausal, fracture history, chronic steroid use | The calcium-regulation axis. Low vitamin D → elevated PTH → calcium pulled from bone. All five tell the story. | 5 | → |
Healthspan biomarkers from the leading protocols.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Longevity Baseline HbA1c · hs-CRP · Lipid · Vitamin D | The four markers most strongly associated with all-cause mortality in cohort studies — glycation, inflammation, lipids, vitamin D. | 4 | → |
| T2 · Confirm | Longevity Advanced Baseline + apoB · Lp(a) · homocysteine · DHEA-S | Adds residual cardiovascular risk (apoB, Lp(a)), methylation (homocysteine), and adrenal reserve (DHEA-S). This is the Attia-style minimum. | 8 | → |
| T3 · Advanced | Longevity Full Stack Advanced + IGF-1 · cortisol · ferritin · fibrinogen | IGF-1 + cortisol round out growth-hormone + stress axes. Ferritin + fibrinogen catch sterile inflammation. The full protocol. | 12 | → |
Training load, recovery, and RED-S.
| Tier | Bundle | Rationale | Markers | |
|---|---|---|---|---|
| T1 · Screen | Athlete Baseline CBC · ferritin · vitamin D · testosterone › Endurance athletes, lifters, heavy training weeks | Endurance athletes run low on iron (depleted ferritin). Low D limits bone + performance. Testosterone flags overtraining + RED-S. | 4 | → |
| T2 · Confirm | Athlete Complete Baseline + iron · magnesium · cortisol · DHEA-S · free T | Full iron studies + magnesium for cramps. Cortisol + DHEA-S together measure HPA load — overtraining flips the ratio. | 9 | → |