also known as Apolipoprotein A-I/Cholesterol in HDL in Serum or Plasma
Apolipoprotein A-1 (apo A-1) has a specific role in the metabolism of lipids and is the main protein component in high-density lipoprotein (HDL, the "good cholesterol"). Like HDL cholesterol, low Apo-A1 level indicates an increased risk of cardiovascular disease while increased concentrations are associated with reduced risk of cardiovascular disease. Apo A-1 may decrease with chronic kidney disease, use of drugs such as: androgens, beta blockers, diuretics, and progestins (synthetic progesterone), smoking, uncontrolled diabetes, and obesity. Increased levels may be seen with the use of drugs such as: carbamazepine, estrogens, ethanol, lovastatin, niacin, oral contraceptives, phenobarbital, pravastatin, and simvastatin, physical exercise, pregnancy, weight reduction, and the use of statins.