also known as Zonulin in Stool
Zonulin is a protein secreted by intestinal cells that regulates intercellular tight junctions which are the connections between epithelial cells that make up the gastrointestinal lining. Zonulin increases intestinal permeability in the jejunum and ileum and is considered a bio marker for barrier permeability. Tight junctions can be opened or closed, depending on the physiological need. Zonulin’s role is to open tight junctions in the gut. In the case of enteric infections, high zonulin can “open the floodgates” and flush out bacteria and toxins. Certain gut bacteria and gliadin (the main staple protein from wheat) can activate the zonulin system.