The Lupus Panel is a specialized blood test designed to help identify Systemic Lupus Erythematosus (SLE), the most common and complex form of lupus. SLE is a chronic autoimmune disease that can affect multiple organs and systems, often presenting with symptoms that fluctuate in severity and are difficult to diagnose without targeted testing. In lupus, the immune system mistakenly attacks healthy tissues, triggering widespread inflammation that may impact the skin, joints, kidneys, heart, lungs, blood vessels, and brain. Because symptoms can vary greatly from person to person and often overlap with other conditions, laboratory testing plays a critical role in uncovering autoimmune activity early. This panel focuses on detecting antinuclear antibodies (ANA), a hallmark finding in lupus, using indirect immunofluorescence (IFA)—the gold standard method for ANA detection. When ANA is positive, reflex testing automatically provides additional disease-specific antibody insights, offering a more precise and informative assessment. By combining sensitive screening with targeted follow-up markers, the Lupus Panel helps clarify whether lupus may be the underlying cause of symptoms, supports earlier diagnosis, and guides next steps for care, monitoring, and treatment planning. What Is Included In This Test? This panel includes advanced antibody testing to evaluate autoimmune activity associated with lupus: ANA Test by IFA (Indirect Immunofluorescence): Detects antinuclear antibodies using the gold standard method for autoimmune screening ANA Reflex Testing (if ANA is positive): ANA titer and fluorescence pattern Double-stranded DNA (dsDNA) antibodies Smith (Sm) antibodies Chromatin antibodies These combined results help determine the presence, pattern, and intensity of autoimmune activity commonly seen in Systemic Lupus Erythematosus. Who Should Consider This Test? This panel is ideal for individuals experiencing symptoms or risk factors commonly associated with lupus. You should consider this test if you: Have persistent joint pain, fatigue, or unexplained fevers Experience skin rashes, especially those triggered by sun exposure Have kidney, neurological, or cardiovascular symptoms of unclear origin Have a family history of lupus or autoimmune disease Are monitoring disease activity or flare risk after a lupus diagnosis Early testing can lead to faster diagnosis, more targeted treatment, and better long-term outcomes. Convenient, No-Appointment Testing To complete your test: Order online through our website Use the lab locator to find a nearby testing location Walk in; no appointment required Access your results securely in your HealthLabs.com account within one to three business days 110% Price Guarantee! If you find the same test for a lower price from a comparable provider, contact us. We not only match the price, we beat it by an additional 10 percent of the difference.